Diagnostic and prognostic value of DNA image cytometry in myelodysplasia.
نویسندگان
چکیده
منابع مشابه
Diagnostic and prognostic value of DNA image cytometry in myelodysplasia.
The DNA content of erythropoietic cells from 10 patients with refractory anaemia (RA) with megaloblastic changes, who subsequently developed acute non-lymphoblastic leukaemia (ANL), and from seven patients with megaloblastic marrow aspirates due to pernicious anaemia were compared by DNA image cytometry. The DNA distribution, the rate of aneuploid cells exceeding 5c (5cER), and the square devia...
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In the fight against cervical malignancy and its precursors, several adjuvant diagnostic methods have been proposed to increase the accuracy of cytologic and histologic diagnoses. Because chromosomal aneuploidy has been accepted as an early key event in tumorigenesis caused by genetic instability, the cytometric equivalent of chromosomal aneuploidy detected by DNA image cytometry (DNA-ICM) may ...
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The report of Raatz, Böcking and Hauptmann [1] represents an excellent example of an in depth retrospective study on the influence of different clinico-pathological parameters including static DNA cytome-try on tumour prognosis illustrating the power but also some limitations of a comprehensive survival analysis in surgical pathology. The authors studied in total 44 neuroendocrine (car-cinoid) ...
متن کاملPrognostic Impact of DNA-Image-Cytometry in Neuroendocrine (Carcinoid) Tumours
Establishing prognosis proves particularly difficult with neuroendocrine tumours (NETs) as a benign looking histology can be associated with a malignant behaviour. In order to identify prognostic factors we examined 44 gastrointestinal and pulmonary, paraffin-embedded NETs histologically and immunohistochemically. DNA-image-cytometry was used to examine 40 of these. We found that poor different...
متن کاملDiagnostic DNA-Flow- vs. -Image-Cytometry in Effusion Cytology
AIMS To determine the sensitivity and specificity of flow- and image-cytometry for the detection of DNA-aneuploidy as a marker for malignant cells in effusions. METHODS 200 effusions (80 tumor cell-positive, 74 negative and 46 cytologically equivocal) were stained with DAPI-SR for DNA-flow- and with Feulgen-Pararosaniline for -image-cytometry. They were measured using a PAS-flow-cytometer and...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1988
ISSN: 0021-9746
DOI: 10.1136/jcp.41.6.604